Long-Term Efficacy and Safety of Raltegravir Combined with Optimized Background Therapy in Treatment-Experienced Patients with Drug-Resistant HIV Infection: Week 96 Results of the BENCHMRK 1 and 2 Phase III Trials
Identifieur interne : 007085 ( Main/Exploration ); précédent : 007084; suivant : 007086Long-Term Efficacy and Safety of Raltegravir Combined with Optimized Background Therapy in Treatment-Experienced Patients with Drug-Resistant HIV Infection: Week 96 Results of the BENCHMRK 1 and 2 Phase III Trials
Auteurs : Roy T. Steigbigel [États-Unis] ; David A. Cooper [Australie] ; Hedy Teppler [États-Unis] ; Joseph J. Eron ; Jose M. Gatell [Espagne] ; Princy N. Kumar [États-Unis] ; Jurgen K. Rockstroh [Allemagne] ; Mauro Schechter [Brésil] ; Christine Katlama [France] ; Martin Markowitz [États-Unis] ; Patrick Yeni [France] ; Mona R. Loutfy [Canada] ; Adriano Lazzarin [Italie] ; Jeffrey L. Lennox [Géorgie (pays)] ; Bonaventura Clotet [Espagne] ; Jing Zhao [États-Unis] ; Hong Wan [États-Unis] ; Rand R. Rhodes [États-Unis] ; Kim M. Strohmaier [États-Unis] ; Richard J. Barnard [États-Unis] ; Robin D. Isaacs [États-Unis] ; Bach-Yen T. Nguyen [États-Unis]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2010-02-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
BENCHMRK-1 and -2 are ongoing double-blind phase III studies of raltegravir in patients experiencing failure of antiretroviral therapy with triple-class drug-resistant human immunodeficiency virus infection. At week 96 (combined data), raltegravir (400 mg twice daily) plus optimized background therapy was generally well tolerated, with superior and durable antiretroviral and immunological efficacy, compared with optimized background therapy alone.
Url:
DOI: 10.1086/650002
Affiliations:
- Allemagne, Australie, Brésil, Canada, Espagne, France, Géorgie (pays), Italie, États-Unis
- Catalogne, District de Cologne, District de Columbia, Lombardie, Nouvelle-Galles du Sud, Ontario, Pennsylvanie, Rhénanie-du-Nord-Westphalie, État de New York, État de Rio de Janeiro, Île-de-France
- Barcelone, Bonn, Milan, Paris, Rio de Janeiro, Sydney, Toronto
- Université Pierre-et-Marie-Curie, Université de Toronto
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000741
- to stream Istex, to step Curation: 000741
- to stream Istex, to step Checkpoint: 000992
- to stream Main, to step Merge: 007619
- to stream PascalFrancis, to step Corpus: 002858
- to stream PascalFrancis, to step Curation: 003728
- to stream PascalFrancis, to step Checkpoint: 002288
- to stream Main, to step Merge: 007D56
- to stream Main, to step Curation: 007085
Le document en format XML
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Rhodes</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Merck Research Laboratories, North Wales</wicri:cityArea></affiliation></author><author><name sortKey="Strohmaier, Kim M" sort="Strohmaier, Kim M" uniqKey="Strohmaier K" first="Kim M." last="Strohmaier">Kim M. Strohmaier</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Merck Research Laboratories, North Wales</wicri:cityArea></affiliation></author><author><name sortKey="Barnard, Richard J" sort="Barnard, Richard J" uniqKey="Barnard R" first="Richard J." last="Barnard">Richard J. Barnard</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Merck Research Laboratories, North Wales</wicri:cityArea></affiliation></author><author><name sortKey="Isaacs, Robin D" sort="Isaacs, Robin D" uniqKey="Isaacs R" first="Robin D." last="Isaacs">Robin D. Isaacs</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Merck Research Laboratories, North Wales</wicri:cityArea></affiliation></author><author><name sortKey="Nguyen, Bach Yen T" sort="Nguyen, Bach Yen T" uniqKey="Nguyen B" first="Bach-Yen T." last="Nguyen">Bach-Yen T. Nguyen</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Merck Research Laboratories, North Wales</wicri:cityArea></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="2010-02-15">2010-02-15</date><biblScope unit="volume">50</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="605">605</biblScope><biblScope unit="page" to="612">612</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Antiretroviral agent</term><term>Antiviral</term><term>Chemotherapy</term><term>Combined treatment</term><term>Human</term><term>Long term</term><term>Phase III trial</term><term>Raltegravir</term><term>Resistance</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Antirétroviral</term><term>Antiviral</term><term>Chimiothérapie</term><term>Essai clinique phase III</term><term>Homme</term><term>Long terme</term><term>Raltégravir</term><term>Résistance</term><term>SIDA</term><term>Traitement associé</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">BENCHMRK-1 and -2 are ongoing double-blind phase III studies of raltegravir in patients experiencing failure of antiretroviral therapy with triple-class drug-resistant human immunodeficiency virus infection. At week 96 (combined data), raltegravir (400 mg twice daily) plus optimized background therapy was generally well tolerated, with superior and durable antiretroviral and immunological efficacy, compared with optimized background therapy alone.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Brésil</li><li>Canada</li><li>Espagne</li><li>France</li><li>Géorgie (pays)</li><li>Italie</li><li>États-Unis</li></country><region><li>Catalogne</li><li>District de Cologne</li><li>District de Columbia</li><li>Lombardie</li><li>Nouvelle-Galles du Sud</li><li>Ontario</li><li>Pennsylvanie</li><li>Rhénanie-du-Nord-Westphalie</li><li>État de New York</li><li>État de Rio de Janeiro</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Bonn</li><li>Milan</li><li>Paris</li><li>Rio de Janeiro</li><li>Sydney</li><li>Toronto</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Eron, Joseph J" sort="Eron, Joseph J" uniqKey="Eron J" first="Joseph J." last="Eron">Joseph J. Eron</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Steigbigel, Roy T" sort="Steigbigel, Roy T" uniqKey="Steigbigel R" first="Roy T." last="Steigbigel">Roy T. Steigbigel</name></region><name sortKey="Barnard, Richard J" sort="Barnard, Richard J" uniqKey="Barnard R" first="Richard J." last="Barnard">Richard J. Barnard</name><name sortKey="Isaacs, Robin D" sort="Isaacs, Robin D" uniqKey="Isaacs R" first="Robin D." last="Isaacs">Robin D. Isaacs</name><name sortKey="Kumar, Princy N" sort="Kumar, Princy N" uniqKey="Kumar P" first="Princy N." last="Kumar">Princy N. Kumar</name><name sortKey="Markowitz, Martin" sort="Markowitz, Martin" uniqKey="Markowitz M" first="Martin" last="Markowitz">Martin Markowitz</name><name sortKey="Nguyen, Bach Yen T" sort="Nguyen, Bach Yen T" uniqKey="Nguyen B" first="Bach-Yen T." last="Nguyen">Bach-Yen T. Nguyen</name><name sortKey="Rhodes, Rand R" sort="Rhodes, Rand R" uniqKey="Rhodes R" first="Rand R." last="Rhodes">Rand R. Rhodes</name><name sortKey="Strohmaier, Kim M" sort="Strohmaier, Kim M" uniqKey="Strohmaier K" first="Kim M." last="Strohmaier">Kim M. Strohmaier</name><name sortKey="Teppler, Hedy" sort="Teppler, Hedy" uniqKey="Teppler H" first="Hedy" last="Teppler">Hedy Teppler</name><name sortKey="Wan, Hong" sort="Wan, Hong" uniqKey="Wan H" first="Hong" last="Wan">Hong Wan</name><name sortKey="Zhao, Jing" sort="Zhao, Jing" uniqKey="Zhao J" first="Jing" last="Zhao">Jing Zhao</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Gatell, Jose M" sort="Gatell, Jose M" uniqKey="Gatell J" first="Jose M." last="Gatell">Jose M. Gatell</name></region><name sortKey="Clotet, Bonaventura" sort="Clotet, Bonaventura" uniqKey="Clotet B" first="Bonaventura" last="Clotet">Bonaventura Clotet</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Rockstroh, Jurgen K" sort="Rockstroh, Jurgen K" uniqKey="Rockstroh J" first="Jurgen K." last="Rockstroh">Jurgen K. 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Loutfy</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="Lazzarin, Adriano" sort="Lazzarin, Adriano" uniqKey="Lazzarin A" first="Adriano" last="Lazzarin">Adriano Lazzarin</name></region></country><country name="Géorgie (pays)"><noRegion><name sortKey="Lennox, Jeffrey L" sort="Lennox, Jeffrey L" uniqKey="Lennox J" first="Jeffrey L." last="Lennox">Jeffrey L. Lennox</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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